Vet Dermatol 2019;30(2):110-e30. 10. Vet Dermatol 2014;25:153 (abstract). 405 HERON DRIVE SUITE 200 SWEDESBORO, NJ 08085-1749 | 2004-2023 WEDGEWOOD PHARMACY, ALL RIGHTS RESERVED. Rosenkrantz WS, Bourgeois AS. Control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age. Intradermal allergy testing is the gold standard for this and involves a veterinary dermatologist subcutaneously injecting very small quantities of potential allergens into a clipped patch of the horses neck. The Feed: One of the most common recommendations for managing Equine Asthma has always been to stop feeding hay. Loft K, Simon B. These animals require the opposite regimen. Treatment success in three Andean bears (Tremarctos ornatus) with alopecia syndrome using Oclacitinib maleate (Apoquel). Pruritus is a common clinical sign in allergic skin diseases. Interestingly, the results suggest that oclacitinib has immunosuppressive properties, but only at a higher dosage than that approved on the label. 27. "Even though the drug is currently labeled for use in dogs (with. In a 3-week trial, the combination of oclacitinib and cyclosporine did not show an increased risk for adverse effects.13, Anecdotal reports indicate that oclacitinib is not very effective in managing recurrent and/or chronic otitis and interdigital furunculosis associated with allergies, and a sudden loss of efficacy is often associated with bacterial or Malassezia overgrowth.14 Sudden withdrawal from oclacitinib can also result in a rapid return of clinical signs, which sometimes appear more severe than before treatment.15, Most recently, it was suggested that the treatment strategy for canine atopic dermatitis might need to be adjusted. With a prescription number, easily refill prescriptions and enroll in the AutoRefill Program. Urticaria (hives) is the most widely reported presentation of a skin allergy. Apoquel starts working within 4 hours of administering the first dose and controls itching within 24 hours. Ordering your pet's prescription drugs from Wedgewood Pharmacy is safe, and convenient. Apoquel is a prescription dog allergy medicine used for the control of itch associated with allergic dermatitis and control of atopic dermatitis in dogs 12 months and older. 19. As the only FDA-approved equine PSGAG (polysulfated glycosaminoglycan) for degenerative joint disease (DJD) in horses, Adequan i.m. Apoquel has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Unlike some other allergy. The biggest disadvantages are the cost, the need to acclimate the horse to having the device placed in his or her nostril, poor tolerance by some horses who dislike the device, and the uncertainty about how long your horse will be able to go without repeating the treatment. 18. Vomiting, diarrhea, and lack of appetite are also possible. Atopic dermatitis is often a complex disease that requires a multifaceted approach. Repeated oral dose tolerance in dogs treated concomitantly with ciclosporin and oclacitinib for three weeks. Ultimately, my vet did not recommend we go down that route. Option 2 is the Aservo Equihaler. Her allergies have reared their ugly heads again - no jowl pyoderma, but ears itching. Vet Dermatol 2016;27(Suppl 1):100 (abstract). Apoquel has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Apoquel is the #1 prescribed medicine for fast, effective relief of allergic itch and inflammation due to atopic and allergic dermatitis 1 Indications Control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age. Ortalda C, Noli C, Colombo S, et al. Use of oclacitinib (Apoquel; Zoetis) for treatment of cutaneous mastocytosis in a cat. (https://www.zoetispetcare.com) I get $9 back for every 30 pills I order, it goes onto a Mastercard debit card that can only be used at a vets office but I spend plenty of money there. I actually have 2 horses now on serum and one I eliminated the food specific allergens from his diet. A native of Japan, Dr. Hensel subsequently moved to Basel, Switzerland, where she opened a veterinary dermatology practice in 2014. Old fashioned drugs like Benadryl and steroids don't work well any more. She reports choosing Apoquel over corticosteroids in several of her allergic patients that are also at risk for developing laminitis. Allergies primarily affect the immune, respiratory, and integumentary (skin) systems and, if unmanaged, can seriously impact an animals performance and well-being. 21. Vet Dermatol 2017;28(5):485-e113. Dawn M. Cleaver, DVM Associate Director, Regulatory Affairs Weve been doing really well with every other day dosing. Gadeyne et al compared prednisolone and oclacitinib at recommended doses and found that both drugs resulted in similar rapid effects with regard to pruritus and dermatitis reduction.11 Little et al compared oclacitinib to cyclosporine. 1,2 The #1 prescribed medicine for allergic itch in dogs. See how Apoquel works differently from steroids and cyclosporines, Discover how Apoquel can relieve allergic itch through an 8-week food trial, Hear from your peers about why Apoquel is their first choice for allergic itch relief, Explore the United States of Apoquel to see how Apoquel has benefited veterinarians in your region, Hear real stories of allergic itch relief from pet owners, See how Zoetis Petcare Rewards can benefit your practice, Informational resources for you to download and utilize within your practice, Provide additional information about Apoquel to pet owners with these resources, Continue therapy once daily (SID) thereafter for maintenance. If the horse is allergic to any of them, his immune system elicits a response, and a hive forms at the injection site. llergies can develop at any time, in any horse, and for virtually any reason. Vet Dermatol 2015;26(4):235-e52. Banovic F, Tarigo J, Gordon H, et al. It is important to address that the use of oclacitinib in cats is off-label, and owners should be informed before using oclacitinib in this species. Option 3 is using a nebulizer with dexamethasone and/or other drugs. The pharmacokinetics of oclacitinib maleate, a Janus kinase inhibitor, in the dog. 17. Like most treatments, this medication will not be successful in every horse, but if it does work, it avoids the risks associated with steroids. After completing a doctorate thesis and a rotating internship at the University of Zurich, Switzerland, he moved to the United States, where he completed a 3-year veterinary dermatology residency at the University of Georgia in 2004. IgE binds to cells in the body and releases inflammatory molecules. Your veterinarian might also prescribe corticosteroids such as dexamethasone or prednisolone, which provide fast and effective relief from immune-mediated conditions such as allergies because of their immunosuppressive properties. I had a cat on it years ago and it was $$$$ but it was the only thing that worked for her. And some can got a lower dose or a further spread out dose. Apoquel can be administered with or without food. Pre-slaughter withdrawal time is 14 days following the last dose. Vet Dermatol 2017;28(5):512-e123. RELATED CONTENT | Infographic: Equine Allergies. 21. See full Excede for Swine Prescribing Information. For atopic and allergic dermatitis, Apoquel may be given to dogs at a dosage of 0.18 - 0.27 mg/lb. The anti-inflammatory effects of dexamethasone are about twenty-five times stronger than those of natural cortisol. Lopes NL, Campos DR, Machado MA, et al. Lopes NL, Campos DR, Machado MA, et al. Interestingly, the results suggest that oclacitinib has immunosuppressive properties, but only at a higher dosage than that approved on the label.30. Fortunately, these side effects are relatively uncommon. This drug has been used in dogs with some pretty fabulous results. $ 78.30 - $ 245.00. It generally reduces itching very quickly within 24 hours and is felt to be as effective as corticosteroids. Unless my vet (and an unaffiliated nutritionist) I consulted are wrong-- I was told that allergy serum is only possible/effective for some allergies and a lot of food-based ones are not on the list. The steroids are usually given orally, but we may want to start with injections for a week or so in severely affected horses. Allergen avoidance and allergen-specific immunotherapy are measures that address the allergy itself; various drugs are available for symptomatic management. Luckily most of her allergies appear to be insect-based and she responds very well to the serum for that. Horse dosing is 5 pills. 25. J Vet Pharmacol Ther 2014;37(3):279-285. He stayed on as a faculty member until 2013, when he decided to move back to Switzerland to open his own dermatology clinic in his hometown of Basel in 2014. The dosages of oclacitinib of 1 mg/kg and 2 mg/kg were chosen because the dosages used for dogs (0.4-0.6 mg/kg) were not shown to be very effective in cats [ 18 ], and the higher dosage range of 0.8-1.3 appeared to be more effective in allergic cats [ 22 ]. J Zoo Wildl Med 2017;48(3):818-828. Im currently struggling with my horses allergies. Specifically, studies in cats have used the following dosage: Initially, doses ranging from 0.4 to 1.2 mg/kg body weight, twice daily, for 24-28 days. Skin allergies can also cause pruritus (itching) and associated hair loss. 23. to 14 days, and then administered once daily for maintenance therapy. Both can be very serious. There are a few medication protocols for horses with Equine Asthma. Several reports of successful use of oclacitinib to treat other diseases have been published.22-29 They include several cases of immune-mediated vascular diseases: idiopathic ear tip vasculitis in 4 dogs26 and ischemic dermatopathy in 6 dogs.28,29 In these reports, other classic medications had failed to control the disease until oclacitinib was added. The dose of APOQUEL tablets is 0.4 mg/kg to 0.6 mg oclacitinib/kg body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. Your Price: $2.20. Gonzales AJ, Bowman JW, Fici GJ, et al. Apoquel Dosage for Dogs. The bodys largest organ, the skin serves as the immune systems first protective barrier. Some states restrict the information we may provide about controlled substances. This includes dietary supplements, shampoos, liniments, fly sprays, coat conditioners, etc. In the past 5 years, however, oclacitinib (Apoquel; ), a Janus kinase (JAK) inhibitor, has become another important drug in the management of allergic pruritus. In cats, this medication can cause excitement rather than sedation. The recommended Apoquel dosage for dogs is 0.18 to 0.27 mg per lb of body weight (0.4-0.6 mg/kg) once a day. 10. I am not saying it is a cure all, but that and some generic Zyrtec make my mare a whole lot more comfortable. found a significant improvement in 76% of horses with skin allergies within one year of using allergen-desensitization serums. 12. Innovation is constantly occurring in the field of immunotherapy. Recently, one group has looked into immunomodulatory properties of oclacitinib by observing canine T-cell proliferation and cytokine productions in vitro. In more severe cases, Apoquel can be given twice per day. Therefore, it is important to get your veterinarian involved right away. All rights reserved. Hay naturally contains microscopic fungal spores, plus bacterial and dust components that horses inhale as they eat, explains Lisa Fultz, DVM, MS, Dipl.