Administer Injectafer intravenously, either as an undiluted slow intravenous push or by infusion. 1) Ganzoni AM. Read our. Applies only to oral form of both agents. Jacobs P, Dommisse J. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hgb conc. Applies only to oral form of both agents. sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was . Minor/Significance Unknown.iron sucrose increases levels of calcium gluconate by enhancing GI absorption. Ferrlecit may also be administered undiluted as a slow intravenous injection (at a rate of up to 12.5 mg/min) per dialysis session. Iron sucrose: 20 mg/mL. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. This calculator will help pinpoint potential causes of anemia based on Before using, check this product visually for particles or discoloration. Applies only to oral form of both agents. Where C= concentration of elemental iron (mg/ml) in the product being used: Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events, Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD), Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD), WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS, Iron Deficiency and Anemia- signs and therapeutic options. Anemia. UpToDate. ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. For iron maintenance treatment, administer Venofer, (2 years of age or older) with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment. Minor/Significance Unknown. Assessing new treatment options. Use Caution/Monitor. The prevention and treatment of iron deficiency is a major public health goal, especially in women, children, and individuals in low-income countries. Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. Talk to your pharmacist for more details.During pregnancy, this medication should be used only when clearly needed. Monitor Closely (1)omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS Fatal and serious hypersensitivity reactions including anaphylaxis have occurred in patients receiving Feraheme. Applies only to oral form of both agents. In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron carboxymaltose); Iron deficiency is common during childhood growth, prolonged periods of sickness, in convalescence or during pregnancy. Minor/Significance Unknown. Alternatively the total dose may be calculated: Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW) Based on: Desired Hb = the target Hb in g/dl. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of mycophenolate by inhibition of GI absorption. This site complies with the HONcode standard for trust- worthy health information: verify here. Applies only to oral form of both agents. restrictions. Avoid or Use Alternate Drug. Minor (2)calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Minor/Significance Unknown. Use Caution/Monitor. Normal haemoglobin values are gender specific: for males from 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and females from 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). 4. Situation Analysis Market Size MAT Sales Cr LC MAT Share % MAT Gr % Total Pharma Market 9388.69 100 13.5 Iron Sucrose 11.18 93.81 37.65 Brand Company Saline MAT . rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Indications: Ferrlecit is an iron replacement product for treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. Use Caution/Monitor. 0.5 mg/kg (not to exceed 100 mg/dose) diluted to a concentration of 1 to 2 mg/mL in 0.9% sodium chloride IV over 5 to 60 minutes Administer every 4 weeks for 12 weeks Do not dilute to concentrations below 1 mg/mL Comments: Treatment may be repeated if necessary. Applies only to oral form of both agents. Consult your pharmacist or local waste disposal company. Intravenous iron replacement can take place as total dose (as in the case of iron-dextran or iron carboxymaltose) or as split dose (in the case of iron sucrose). Use Caution/Monitor. Do not administer Venofer to patients with evidence of iron overload. 2010;18(3). Modify Therapy/Monitor Closely. Immune system disorders: Anaphylactic-type reactions, angioedema, Nervous system disorders: Convulsions, collapse, light-headedness, loss-of-consciousness, Respiratory, thoracic and mediastinal disorders: Bronchospasm, dyspnea, Musculoskeletal and connective tissue disorders: Back pain, swelling of the joints, General disorders and administration site conditions: Hyperhidrosis, Published studies on intravenous iron sucrose treatment after first trimester of pregnancy not shown adverse maternal or fetal outcomes; available reports of intravenous iron sucrose use in pregnant women during first trimester are insufficient to assess risk of major birth defects and miscarriage; iron deficiency anemia during pregnancy should be treated because there are risks to mother and fetus associated with untreated iron deficiency anemia (IDA) in pregnancy; risks to fetus associated with maternal severe hypersensitivity reactions, Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products which may cause fetal bradycardia, especially during second and third trimester, Iron sucrose is present in human milk, and available published reports following exposure to 100-300 mg intravenous iron sucrose have not reported adverse reactions in breastfed infants; there are no data on effects on milk production, Developmental and health benefits of breastfeeding should be considered, along with mothers clinical need for treatment and any potential adverse effects on breastfed child from therapy or from underlying maternal condition. Avoid or Use Alternate Drug. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. This cost includes the fee charged by the pharmacy. iron sucrose increases levels of calcium chloride by enhancing GI absorption. Interaction only with oral iron administration. Always ask your health care professional for complete information about this product and your specific health needs. If hypersensitivity reactions or signs of intolerance occur during administration, stop Venofer immediately. Use Caution/Monitor. Separate by 2 hr. 2010;18(3). Pain, swelling, or redness at the injection site may occur. Use Caution/Monitor. 1988 May;111(5):566-70. Applies only to oral form of both agents. No data are available regarding overdosage of Venofer in humans. Separate dosing of tetracyclines from these products. Hypotension following administration of Venofer may be related to rate of administration and/or total dose delivered. Use alternatives if available. Separate by at least 4 hours. Serious - Use Alternative (1)iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Monitor Closely (1)cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Applies only to oral form of both agents. iron sucrose decreases levels of manganese by inhibition of GI absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. Avoid or Use Alternate Drug. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDDCKD has not - been established. Applies only to oral form of both agents. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Applies only to oral form of both agents. Use Caution/Monitor. Andreas M. Ganzoni, MD, is a physician and researcher in the internal medicine department at the University of Zurich in Zurich, Switzerland. Use Caution/Monitor. Administer on 5 different occasions over a 14 day period. Use Caution/Monitor. Applies only to oral form of both agents. Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events. Diagnosis and management of iron deficiency anaemia: a clinical update. Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Dr. Ganzonis primary research is focused on iron deficiency and plasma iron transport. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session [see How Supplied/Storage and Handling (16.2).] Minor (2)calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. These can be input in g/dL, g/L or mmol/L. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14 [see How Supplied/Storage and Handling (16.2). Either decreases levels of the other by inhibition of GI absorption. Avoid or Use Alternate Drug. Applies only to oral form of both agents. [. Get in touch with MDApp by using the following contact details: 2017 - 2023 MDApp. Minor/Significance Unknown. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. To view formulary information first create a list of plans. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Interaction only with oral iron administration. There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. commonly, these are "non-preferred" brand drugs or specialty Anemia; 2015: 763576. Your doctor will do laboratory tests to monitor your response. It varies from increases in dietary intake of iron (usually for prophylaxis purposes) to oral, intramuscular or intravenous therapy. Venofer is given as an infusion into a vein. Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. * Adapted from the KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. There are four fields that need to be completed: Weight body weight is used to establish iron deficit and is also taken into account when estimating the iron stores. Hemoglobin iron deficit = 60 x (14 - 8) x (2.145) = 772 mg iron. Properly discard this product when it is expired or no longer needed. In the text below the tool there is more information on how the iron deficit is calculated. Use Caution/Monitor. Avoid or Use Alternate Drug. omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Drug class: Iron products. Share cases and questions with Physicians on Medscape consult. didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Below the form there are further instructions on how to use the calculator. Applies only to oral form of both agents. Treatment of anemia due to iron deficiency. Venofer treatment may be repeated if iron deficiency reoccurs. Applies only to oral form of both agents. Minor/Significance Unknown. Avoid or Use Alternate Drug. 1974 Jun;31(6):592-5. 3) Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. (1988) Clinical use of the total dose intravenous infusion of iron dextran. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Parenteral Iron Replacement For Iron Deficiency Anemia Calculator, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Clinical use of the total dose intravenous infusion of iron dextran, When is high-dose intravenous iron repletion needed? Give each dose as 750mg for a total cumulative dose not to exceed1500mg of ironper course. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. Applies only to oral form of both agents. Bhowmik D, Modi G, Ray D, Gupta S, Agarwal SK, Tiwari SC, Dash SC. The factor 2.4 comes about from the calculation that the total iron content of hemoglobin is 0.34%, the blood volume accounts for 7% . Observed Hb = the patients current hemoglobin in g/dl. The dosing for iron replacement treatment in pediatric patients with HDD-CKD has not been established. Written by ASHP. Where C is the concentration of the iron product: Please note that the calculations above are for information purposes only and the individual dose needs to be established by taking into account the current package insert for the elemental iron product used. Recommended starting dose 1 Aranesp is dosed at 2.25 mcg/kg SC QW or 500 SC Q3W 1 (SC = subcutaneous) Before initiating 1: Evaluate iron status; administer supplemental iron therapy as needed Correct or eliminate other causes of anemia Initiate 1: Only when Hb < 10 g/dL Applies only to oral form of both agents. You can further save the PDF or print it. Otherwise, call a poison control center right away. Serious - Use Alternative (1)iron sucrose decreases levels of minocycline by inhibition of GI absorption. ONE DOSE. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=abacb7fa-2fc2-471e-9200-944eeac8ca2a. Avoid or Use Alternate Drug. Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Use Caution/Monitor. Use Caution/Monitor. View the formulary and any restrictions for each plan. If these effects continue or worsen, tell your doctor.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. David McAuley, Pharm.D. SIDE EFFECTS: Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. Use Caution/Monitor. Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). Venofer (Iron Sucrose Injection) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Dosage form: injection, solution Minor/Significance Unknown.iron sucrose increases levels of calcium chloride by enhancing GI absorption. Allow at least 30 minutes between administration of Feraheme and administration of other medications that could potentially cause serious hypersensitivity reactions and/or hypotension, such as chemotherapeutic agents or monoclonal antibodies. For adult CKD patients on ESA therapy who are not receiving iron supplementation, the guideline suggests a trial of IV iron (or in NDD-CKD patients, alternatively, a 1- to 3-month trial of oral iron therapy) if: CKD=chronic kidney disease ESA=erythropoietin-stimulating agent Hb=hemoglobin IV=intravenous RBC=red blood cell WBC=white blood cell. Suggested regime: Prescribing instructions Prescribing a single/first dose: Venofer® (iron sucrose) injection, USP is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling (16.2).] FERAHEME was non-inferior to Venofer (iron sucrose) in mean Hgb rise from baseline 2,5. iron sucrose decreases levels of deferiprone by enhancing GI absorption. Injection site discoloration has been reported following extravasation. Use Caution/Monitor. If either is present, do not use the liquid. Safety of highdose iron sucrose infusion in hospitalized patients with chronic kidney disease. Minor/Significance Unknown. famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. A healthcare provider will give you this injection. iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. This product may contain inactive ingredients, which can cause allergic reactions or other problems. iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Use Caution/Monitor. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. After administration of iron dextran complex, evidence of a therapeutic response can be seen in a few days as an increase in the reticulocyte count. Applies only to oral form of both agents. Applies only to oral form of both agents. I. Treatment of anemia due to iron deficiency. . Separate by at least 4 hours. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. The iron deficit calculator is useful as one of the determinations performed before iron replenishment therapy is initiated. Serious - Use Alternative (1)iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. This parenteral iron replacement for iron deficiency anemia calculator determines the parenteral dose of iron supplement needed to replenish iron stores and hemoglobin levels. Use Caution/Monitor. FOR PATIENTS WEIGHING 50 kg OR MORE: Administer 1000 mg of Monoferric by intravenous infusion 20 minutes as a single dose 1. Avoid or Use Alternate Drug. Anemia caused by the depletion of iron is called iron deficiency anemia. Applies only to oral form of both agents. Use Caution/Monitor. The dosage of Venofer is expressed in mg of elemental iron. Information last revised December 2022. Monitor Closely (1)iron sucrose decreases levels of deferiprone by enhancing GI absorption. Elemental iron product this is a choice between three iron supplement products: Iron dextran 50 mg/mL, Iron sucrose 20 mg/mL and Ferric gluconate 12.5 mg/mL. Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf. Use Caution/Monitor.Minor (2)calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD): Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl x 15 minutes. Congenital Pulmonary Airway Malformation Volume Ratio (CVR) Calculator -. You may report side effects to Health Canada at 1-866-234-2345. Applies only to oral form of both agents. When to Use Weight lbs Target hemoglobin g/dL Actual hemoglobin g/dL Iron stores Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg mg Result: Please fill out required fields. Monitor Closely (1)iron sucrose decreases levels of liothyronine by inhibition of GI absorption. Max Dose. Monitor Closely (1)iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator If we don't have the calculator you need then tell us the details and we'll make it for you. sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. Manage and view all your plans together even plans in different states. Monitor Closely (1)trientine, iron sucrose. Applies only to oral form of both agents. Minor (2)calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. Schweiz Med Wochenschr; 100(7):301-3. Creating an account is free and takes less than 1 minute. FERAHEME Dosing & Administration - Feraheme FERAHEME has flexible dosing for your patients FERAHEME flexible scheduling gives your patients the freedom to receive the iron they need as early as 3 days apart 1 FLEXIBLE DILUTION OPTIONS 1 Dilute full contents of vial (17 mL) in 50 mL to 200 mL of: 0.9% NaCl, or 5% dextrose STORAGE 1 Use Caution/Monitor. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Use Caution/Monitor. Each mL contains 20 mg of elemental iron. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. Access your plan list on any device mobile or desktop. Fatal reactions have also occurred in situations where the test dose was tolerated. iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Monitor Closely (1)calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. The weight of the patient is taken into account in order to estimate iron stores, while haemoglobin is required as both current measured and target. Discuss the risks and benefits with your doctor.This medication passes into breast milk. Dosing: (a) Divide calculated total cumulate dose . If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. The factor 2.4 is derived from the following assumptions: a) Blood volume 70 ml/kg of body weight ~7% of body weight b) Iron content of hemoglobin 0.34% Factor 2.4 = 0.0034 x 0.07 x 10000 (conversion for g/dL) Ganzoni AM. calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Copyright(c) 2023 First Databank, Inc. official version of the modified score here. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. When iron sucrose was administered at deliberate overdoses to rabbit dams (up to 215 mg/kg/day) marked fetal/placental iron overload was noted. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)- . In: Koda-Kimble & Young's Applied Therapeutics: The Clinical Use of Drugs. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling [16.2].) 2000 Jan;22(1):39-43. 2 *Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with CKD. Applies only to oral form of both agents. 1996 Aug;11(4):139-46. prescription products. Applies only to oral form of both agents. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14. Then you can click on the Print button to open a PDF in a separate window with the inputs and results. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: vitamin products, other iron-containing products. No additional iron to replenish stores. Venofer (iron sucrose injection, USP) For Intravenous Use Only INDICATION AND USAGE Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Administer Venofer only intravenously by slow injection or by infusion. Use Caution/Monitor. Use Caution/Monitor. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. and formulary information changes. naia basketball records,